2-[N-(2,4-Dimethoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate
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چکیده
منابع مشابه
Ethyl 2-hydroxy-2-phenyl-2-(thiazol-2-yl)acetate
This short note describes the synthesis of the title compound through spontaneous aerobic oxidation of ethyl 2-phenyl-2-(thiazol-2-yl)acetate. Due to the prevalence of such functional motifs in biologically active substances, we believe the oxidation encountered highlights an important degradation pathway worthy of note.
متن کامل2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate
The structural analysis of the title compound, C14H14N2O4S, particularly the presence of an acetyl group at the exocyclic N atom and the C(H)-C(O2CMe)-N acet-oxy group in the thia-zole ring, may indicate that one of the starting materials, i.e. 2-(4-meth-oxy-anilino)-1,3-thia-zol-4(5H)-one, exists in the reaction mixture, at least partially, as a tautomer with an exocyclic amine N atom and an e...
متن کاملN - ( 4 - Methoxyphenyl ) - N 0 - ( 5 - nitro - 1 , 3 - thiazol - 2 - yl ) urea
Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6, PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada M5T 1R8, and Departments of Chemistry and Chemical Biology, and Medical Physics and Applied Radiation Sciences, McMaster University, 1280 Main St...
متن کامل2-[N-(2,4-Dimethoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate
The title compound, C15H16N2O5S, is a product of the reaction of 2-(2,4-dimeth-oxy-phenyl-amino)-1,3-thia-zol-4(5H)-one with acetic anhydride. The presence of the acetyl and acet-oxy groups in the mol-ecule indicates that the starting thia-zole exists as a tautomer in the reaction mixture with exocyclic amino and enol moieties. The acetyl group is tilted slightly from the heterocyclic ring plan...
متن کاملDiscovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitotic histone H3 phosphorylation, and caused aberrant mitotic phenotypes. It was subsequently established that these compounds were in fact potent inhibitors of aurora A and B kina...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2013
ISSN: 1600-5368
DOI: 10.1107/s1600536813003474